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. 2013 Jul;142(1):75–85. doi: 10.1085/jgp.201310985

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© 2013 Rowe et al.

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Figure 7. — I-V relationships for single-channel currents recorded in control and in the presence of 1 M trehalose on the cytoplasmic side for MscL-like and MscS-like channels in V. cholerae. (A and B) Each plot presents the data of one typical experiment, with all I-V curves obtained on the same patch. The unilateral addition of trehalose decreased the slope conductance by a factor of 0.78 ± 0.03 for MscL-like and by a factor of 0.80 ± 0.06 for MscS-like channels (mean ± SD; n = 4; based on four independent experiments). (C) Model of a channel, depicting how the total series resistance (Rtot) is determined by the pore itself (Rp) as well as the access resistance on either side of the membrane (Rs₁ and Rs₂). The values are dependent on channel radius (a), length (l), and the conductivity of the solution (ρ), which can be found in Table 2. Shaded area on the left represents the compartment with trehalose.