Table 1.

IVM to study tissue physiopathology

Event	Organ	Probes	Reference
Measurements of local blood flow and glial cell function	Brain	Dextran	Helmchen and Kleinfeld, 2008
Ischemia and reperfusion	Brain	Sulphorhodamine 101, Dextran	Zhang and Murphy, 2007; Masamoto et al., 2012;
Glomerular filtration and tubular reabsorption	Kidney	Dextran, Albumin	Kang et al., 2006; Yu et al., 2007; Camirand et al., 2011
Blood flow patterns	Pancreatic islets	Dextran	Nyman et al., 2008
Capillary response and synaptic activation	Olfactory bulb	Dextran	Chaigneau et al., 2003
Imaging angiogenesis during wound healing	Skullcap	Dextran	Holstein et al., 2011
Pulmonary microvasculature and endothelial activation	Lung	Dextran	Presson et al., 2011
Morphology of blood vessels and permeability in tumors	Xenografts	Dextran, RGD quantum dots	Tozer et al., 2005; Smith et al., 2008; Vakoc et al., 2009; Fukumura et al., 2010
Hepatic transport into the bile canaliculi	Liver	Carboxyfluorescein diacetate Rhodamine 123	Babbey et al., 2012; Liu et al., 2012
Progression of amyloid plaques in Alzheimer’s disease	Brain	Curcumin and metoxy-04	Spires et al., 2005; Garcia-Alloza et al., 2007
Mitochondrial membrane potential	Liver	Tetramethylrhodamine methyl ester Rhodamine 123	Theruvath et al., 2008; Zhong et al., 2008
Oxygen consumption	Liver	Ru(phen3)2+	Paxian et al., 2004
Sarcomere contraction in humans	Skeletal muscle	Endogenous fluorescence	Llewellyn et al., 2008