TABLE 3.

Criteria for treatment failure at 48 hours and 5 days

Criterion for treatment failure at 48 hours	Frequency at 48 hours N=111	Frequency at 5 days N=62
Worsening conscious level	4 (3.6%)	3 (5%)
Persistent reduced conscious level	-	0 (0%)
Worsening SaO2	19 (17%)	2 (3%)
Persistent SaO2 <90%	-	19 (31%)
Worsening respiratory rate	61 (55%)	12 (19%)
Persistent respiratory rate	-	5 (8%)
Worsening temperature	22 (20%)	1 (2%)
Persistent temperature	-	4 (6%)
Persistent lower chest wall indrawing	-	31 (50%)
New empyema	0 (0%)	0 (0%)
New bacterial meningitis	2 (1.8%)	2 (3%)
New renal impairment	0 (0%)	1 (2%)
New signs of shock	3 (2.7%)	4 (6%)
Death	22 (20%)	25 (40%)

Note: proportions exceed 100% as children may have had more than one reason for failure, there is no overlap with ‘death’.