TABLE 4.
Risk of Death for VLBW Infants in the NRN Cohort Born in 1998–2007 With and Without a Major BD
| Infants With BDs, N = 1776 | Infants Without BDs, N = 35 486 | Adjusted RR for Death (95% CI) BD Versus No BDa | P a | |
|---|---|---|---|---|
| Survived | 898 (51) | 29 003 (82) | ||
| Died | 878 (49) | 6483 (18) | 3.66 (3.41–3.92) | <.001 |
| Died ≤ 12 h | 326 (18) | 2401 (7) | 3.83 (3.37–4.36) | <.001 |
| Died ≤ 3 db | 460 (26) | 3421 (10) | 3.77 (3.40–4.19) | <.001 |
| Deaths by BW, g | ||||
| 401–500 | 51 (86) | 1249 (83) | 1.06 (0.94–1.19) | .37 |
| 501–750 | 177 (67) | 3520 (46) | 1.46 (1.33–1.59) | <.001 |
| 751–1000 | 203 (48) | 1102 (14) | 3.48 (3.10–3.90) | <.001 |
| 1001–1250 | 210 (45) | 411 (5) | 9.22 (8.02–10.60) | <.001 |
| 1251–1500 | 237 (42) | 201 (2) | 20.07 (16.94–23.79) | <.001 |
| Deaths by GA, wk | ||||
| <22 | 20 (100) | 354 (99) | 0.98 (0.91–1.06) | .59 |
| 22–24 | 114 (77) | 3632 (62) | 1.24 (1.12–1.37) | <.001 |
| 25–28 | 297 (51) | 2127 (14) | 3.39 (3.10–3.70) | <.001 |
| 29–32 | 318 (43) | 343 (3) | 14.07 (12.28–16.11) | <.001 |
| 33+ | 128 (45) | 24 (1) | 35.58 (23.21–54.57) | <.001 |
RRs, CIs, and P values by the Score χ2 test for the overall cohort from modified Poisson regression models that included study center, GA (<22, 22–24, 25–28, 29–32, 33+), SGA, male gender, race/ethnicity (non-Hispanic black, non-Hispanic white, Hispanic, other), and the BDs indicator. RRs, CIs, and P values by the Wald χ2 for each GA group from a similar model that included effects for the interaction of GA group and the BDs indicator. BW was substituted for GA and SGA in the model examining deaths by BW, which also included effects for the interaction between BW group and the BDs indicator.
Timing of death after 12 h could not be determined for 1 infant with a BD due to missing date of death.