Table 2.

Simulation results for the probability of treatment failure when resistance is costly

DOI: http://dx.doi.org/10.7554/eLife.00747.011

Dual therapy:		Number of cells	Birth rate	Probability of treatment failure
n1 = n2	n12			c = 0%	c = 1%	c = 5%	c = 10%
50	0	109	0.14	0.0	0.0	0.0	0.0
50	0	109	1	0.01	0.01	0.01	0.0
50	1	109	0.14	0.74	0.73	0.72	0.7
50	1	109	1	0.74	0.74	0.72	0.7
50	0	1011	0.14	0.12	0.11	0.08	0.06
50	0	1011	1	0.53	0.51	0.42	0.32
50	1	1011	0.14	1.0	1.0	1.0	1.0
50	1	1011	1	1.0	1.0	1.0	1.0

Each resistance mutation reduces the net growth rate by a factor c via a decrease of the birth rate b. Parameter values are death rate, d = b − 0.01, death rate for sensitive cells during treatment, d’ = b + 0.03, point mutation rate, u = 10⁻⁹. The simulation results are averages over 10⁶ runs per parameter combination.