Table 4. Sensitivity analysis.
| ICER (GBP/QALY) | |||
|---|---|---|---|
|
| |||
| Scenarios assessing proportion of HRQoL and mortality benefit | BKP vs NSM | BKP vs PVP - PVP effect constant |
BKP vs PVP - PVP effect varies with BKP effect |
| Mortality benefit varied | |||
| 75% mortality reduction | 3,104 | 32,419 | 20,879 |
| 50% mortality reduction | 3,646 | Dominated | 29,970 |
| 25% mortality reduction | 4,431 | Dominated | 52,665 |
| No mortality reduction | 5,667 | Dominated | 210,188 |
| HRQoL benefit varied | |||
| 75% HRQoL benefit | 3,059 | 27,764 | 16,330 |
| 50% HRQoL benefit | 3,517 | 105,638 | 16,697 |
| 25% HRQoL benefit | 4,136 | Dominated | 17,084 |
| No mortality reduction - HRQoL benefit varied | |||
| 75% HRQoL benefit | 7,556 | Dominated | 278,837 |
| 50% HRQoL benefit | 11,334 | Dominated | 415,947 |
| 25% HRQoL benefit | 22,668 | Dominated | 826,858 |
| Other Scenarios | BKP vs NSM | BKP vs PVP |
|---|---|---|
| With full mortality reduction with BKP and PVP | ||
| No offset time | 2,919 | 16,249 |
| No bisphosphonate treatment | 2,764 | 16,305 |
| Increased fracture risk with BKP | 3,503 | 24,904 |
| PVP price set at 0% of BKP price | 2,706 | 29,606 |
| PVP price set at 50% of BKP price | 2,706 | 14,914 |
| PVP price set at 75% of BKP price | 2,706 | 7,568 |
| 0 days reduction with BKP and PVP in length of stay | 8,132 | 15,982 |
| 3 days reduction with BKP and PVP in length of stay | 5,419 | 15,982 |
| 9 days reduction with BKP and PVP in length of stay | Cost saving | 15,982 |
| 0% discount rate (with mortality reduction) | 2,224 | 11,922 |
| 7% discount rate (with mortality reduction) | 3,193 | 20,661 |
| 60 year old patients (with mortality reduction) | 2,912 | 19,249 |
| 80 year old patients (with mortality reduction) | 2,373 | 12,038 |
| Without mortality reduction with BKP and PVP | ||
| No offset time | 6,705 | 250,997 |
| No bisphosphonate treatment | 5,743 | 212,001 |
| Increased fracture risk with BKP | 7,904 | Dominated |
| PVP price set at 0% of BKP price | 5,667 | 391,868 |
| PVP price set at 50% of BKP price | 5,667 | 195,939 |
| PVP price set at 75% of BKP price | 5,667 | 97,969 |
| 0 days reduction with BKP and PVP in length of stay | 17,557 | 210,188 |
| 3 days reduction with BKP and PVP in length of stay | 11,612 | 210,188 |
| 9 days reduction with BKP and PVP in length of stay | Dominating | 210,188 |
| 0% Discount rate | 5,392 | 203,712 |
| 7% Discount rate | 5,949 | 216,711 |
| 60 year old patients | 5,507 | 206,515 |
| 80 year old patients | 5,905 | 215,739 |