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Mitochondrial swelling is inhibited in mice with cardiac-specific expression of active but not inactive PKCε. Mitochondria were isolated from NTG, AE, and DN hearts, and swelling was induced by 200 μmol/L CaCl2 and measured spectrophotometrically as a decrease in A520. Figure shows representative traces for NTG, AE, and DN mitochondria (n=4).
