Table 1.

Domino synthesis of indoles 4 under MW^a

Entry	Product	R or R′	Time/min	Yieldb/%
1	4a–4d	4a, H (1a)	18	85
2		4b, 4-Fluoro (1b)	20	81
3		4c, 4-Bromo (1d)	22	82
4		4d, 4-Methyl (1e)	16	88
5	4c–4j	4e, H (1a)	18	86
6		4f, 4-Fluoro (1b)	24	82
7		4g, 4-Chloro (1c)	20	84
8		4h, 4-Bromo (1d)	18	85
9		4i, 4-Methyl (1e)	16	87
10	4k–4n	4j, 4-Methoxy (1f)	15	89
11		4k, 4-Chloro (1b)	22	79
12		4l, 4-Bromo (1d)	20	75
13		4m, 4-Methyl (1e)	18	81
14		4n, 4-Ethoxy (1f)	18	84
15	4o–4s	4o, 4-Fluoro (1b)	26	82
16		4p, 4-Chloro (1c)	22	77
17		4q, 4-Bromo (1d)	22	79
18		4r, 4-Methyl (1e)	18	84
19		4s, 4-Methoxy (1f)	18	85
20	4t–4v	4t, Methyl (3a)	20	79
21		4u, Ethyl (3b)	22	76
22		4w, Propyl (3c)	22	78
23		4v, Isopropyl (3d)	20	80

^aReagents and conditions: 120 °C, microwave heating.

^bIsolated yield.