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. Author manuscript; available in PMC: 2013 Jun 25.
Published in final edited form as: Cardiovasc Res. 2004 Oct 1;64(1):61–71. doi: 10.1016/j.cardiores.2004.05.011

Fig. 5.

Fig. 5

Tyrosine phosphorylation of JAK1 and JAK2 by ischemic PC in wild-type and IL-6−/− mice. Myocardial samples were obtained from mice that underwent a sham operation (control) and from the ischemic/reperfused region of preconditioned (PC) wild-type and IL-6−/− mice. All mice were euthanized 5 min after the sixth reperfusion. Upper panels: Western blots showing that the immunoreactivity of the tyrosine-phosphorylated forms of JAK1 (panel A) and JAK2 (panel B) increased markedly 5 min after ischemic PC in wild-type mice, and that this increase was ablated in preconditioned IL-6−/− mice. Lower panels: Densitometric analysis of tyrosine-phosphorylated JAK1 and JAK2 signals. Data are mean ± S.E.M.