Table 1. IC50 Values for Complexes 1–4 in A2780 Cellsa and Mean GI50 and LC50 Values for the NCI-60 Panel of Cell Lines.
| complex | A2780 IC50 (μM) | mean GI50 (μM) | mean LC50 (μM) |
|---|---|---|---|
| (1) [Ir(η5-Cpxbiph)(phen)Cl]PF6 | 0.72 ± 0.0112 | 2.34 | 31.62 |
| (2) [Ir(η5-Cpxbiph)(bpy)Cl]PF6 | 0.57 ± 0.0912 | 4.17 | 67.61 |
| (3) [Ir(η5-Cpxbiph)(ppy)Cl] | 0.70 ± 0.0413 | 0.71 | 8.13 |
| (4) [Ir(η5-Cpxph)(NMe2-azpy)Cl]PF6 | 0.40 ± 0.03 | 0.59 | 6.61 |
| cisplatin | 1.20 ± 0.20 | 1.49 | 44.00 |
a
Mean ± standard deviation from two independent experiments, with triplicate measurements in each experiment.