Table 1.
Baseline characteristics stratified by eGFR level
| Variables | All |
eGFR Level |
P value | ||
|---|---|---|---|---|---|
| < 20 ml/min | 20-29 ml/min | ≥ 30 ml/min | |||
| N |
2402 |
533 (22%) |
933 (39%) |
936 (40%) |
|
| Age (in years) |
68.1 (12.7) |
66.9 (13.5) |
68.7 (12.6) |
68.3 (12.3) |
0.033 |
| Gender (% Male) |
1502 (63%) |
311 (58%) |
569 (61%) |
622 (66%) |
0.004 |
| Race (% Caucasian) |
2142 (89%) |
471 (88%) |
834 (89%) |
837 (89%) |
0.79 |
| Diabetes |
1160 (48%) |
251 (47%) |
480 (51%) |
429 (46%) |
0.043 |
| Primary Kidney Disease |
|
|
|
|
|
| Diabetic Nephropathy |
699 (29%) |
167 (31%) |
291 (31%) |
241 (26%) |
<0.0001 |
| Hypertensive Nephropathy |
637 (27%) |
124 (23%) |
248 (27%) |
265 (28%) |
|
| Glomerulonephritis |
273 (11%) |
75 (14%) |
104 (11%) |
94 (10%) |
|
| Polycystic Kidney Disease |
103 (4%) |
29 (5%) |
33 (4%) |
41 (4%) |
|
| Other |
690 (29%) |
138 (26%) |
254 (28%) |
295 (32%) |
|
| eGFR mL/min/1.73m2 |
27.9 (9.0) |
16.8 (2.0) |
24.9 (2.9) |
37.2 (5.6) |
<0.0001 |
| Albumin g/L |
40.4 (4.2) |
39.7 (4.5) |
40.4 (4.1) |
40.8 (4.3) |
<0.0001 |
| Hemoglobin g/L |
122 (16) |
117 (14) |
123 (14) |
127 (17) |
<0.0001 |
| Cholesterol mmol/L |
4.25 (1.17) |
4.13 (1.21) |
4.28 (1.09) |
4.29 (1.23) |
0.17 |
| Calcium mmol/L |
2.30 (0.14) |
2.27 (0.15) |
2.30 (0.14) |
2.32 (0.14) |
<0.0001 |
| Phosphate mmol/L |
1.22 (0.26) |
1.37 (0.26) |
1.22 (0.22) |
1.13 (0.24) |
<0.0001 |
| 1,84 Parathyroid Hormone pg/mL |
44 (21–69) |
76 (46–122) |
41 (31–85) |
33 (20–48) |
<0.0001 |
| Bicarbonate mmol/L |
25.4 (3.6) |
24.1 (4.0) |
25.1 (3.4) |
26.6 (3.2) |
<0.0001 |
| ACR mg/mmol |
16 (3–88) |
54 (13–209) |
18 (3–87) |
7 (2–43) |
<0.0001 |
| ACR |
|
|
|
|
|
| < 3.4 mg/mmol |
632 (27%) |
50 (11%) |
222 (25%) |
348 (36%) |
<0.0001 |
| 3.4-33.9 mg/mmol |
818 (34%) |
137 (30%) |
321 (36%) |
347 (36%) |
|
| 34.0-113.0 mg/mmol |
410 (17%) |
109 (24%) |
157 (17%) |
137 (14%) |
|
| > 113.0 mg/mmol |
512 (22%) |
167 (36%) |
198 (22%) |
137 (14%) |
|
| Cystatin C ng/mL |
1888 (539) |
2419 (469) |
1957 (424) |
1519 (373) |
<0.0001 |
| ADMA μM |
0.543 (0.113) |
0.557 (0.117) |
0.548 (0.113) |
0.529 (0.112) |
<0.0001 |
| NT-pro-BNP pg/mL |
465 (186–1359) |
771 (297–2350) |
515 (227–1235) |
314 (130–940) |
<0.0001 |
| CRP mg/L |
2.9 (1.2-6.7) |
3.4 (1.4-7.3) |
2.9 (1.1-6.7) |
2.7 (1.1-6.1) |
0.026 |
| TGF β1 pg/mL |
19838 (15919–25085) |
18343 (14365–22865) |
19803 (15936–24729) |
21043 (16678–26467) |
<0.0001 |
| IL6 μg/L |
4.4 (1.0-7.1) |
4.8 (1.0-7.8) |
4.5 (1.0-7.2) |
4.1 (1.0-6.7) |
<0.0001 |
| Troponin I > LLD |
910 (37%) |
244 (44%) |
360 (38%) |
306 (31%) |
<0.0001 |
| 25-hydroxyvitamin D ng/mL | 23.9 (16.3-33.4) | 21.2 (14.4-30.9) | 23.7 (16.0-33.5) | 26.0 (17.9-35.0) | <0.0001 |
*LLD: Lower Detection Limit.