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. 2013 Jun 17;13:61. doi: 10.1186/1475-2867-13-61

Figure 4.

Figure 4

Shows E7 mediated inhibition of pRB that results in sequestration of E2F. E2F moves into the nucleus to stimulate the expression of miR-15b. E7 also directly represses miR-203 expression. Additionally, p53 triggers expression of miR-145, miR-23b and miR-34a. Therefore E7 indirectly repress the expression of target miRNAs by degrading p53. miRNAs in slanting boxes are over-expressed in cervical cancer cells. Rectangular Boxes indicate post-transcriptional processing of gene subsets bi miRNAs.