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. 2013 Jun 6;10:182. doi: 10.1186/1743-422X-10-182

Figure 2.

Figure 2

The HPV proteins involved in apoptotic signaling pathways. A) The Human Papillomavirus Virus genome. All HPVs have a common genomic organization and encode 8 proteins: E1, E2, E4, E5, E6 and E7 (early) and L1 and L2 (late). B) Participation of HPV proteins in apoptotic pathways. E5 impairs the formation of the death-inducing signaling complex triggered by FasL and TRAIL. E6 targets pro-apoptotic proteins such as p53, Bax and Bak for proteolytic degradation; in contrast, E6 can also induce the expression of IAPs. E7 promotes the degradation of the anti-apoptotic protein, pRb, releasing E2F-1. E2 induces apoptosis via the downregulation of E6/E7 mRNA; or direct binding and activation of procaspase 8; or when it binds to p53. Modified from Lagunas-Martínez A. et al. (2010) [49].