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. 2013 Jun 6;10:182. doi: 10.1186/1743-422X-10-182

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Copyright © 2013 Fuentes-González et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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EBV genome. Location and transcription of the EBV latent genes on the double-stranded viral DNA episome. The bottom arrows represent coding exons for each of the latent proteins; the latent proteins include the six nuclear antigens (EBNAs 1, 2, 3A, 3B and 3C, and EBNA-LP) and the three latent membrane proteins (LMPs 1, 2A, 2B). EBNA-LP is transcribed from variable numbers of repetitive exons. The arrows with the discontinuous lines close together at the top represent the highly transcribed nonpolyadenylated RNAs EBER1 and EBER2; their transcription is a consistent feature of latent EBV infection. EBNAs are transcribed from either the Cp or Wp promoter.