Figure 6.

Different KSHV proteins inhibit intrinsic and extrinsic apoptotic pathways. vFLIP directly binds to death effector domains, or to the TRAF complex, inhibiting activated-Fas signaling, or activating NF-kB. Both vIAP and vBCL-2 act at the mitochondria to stabilize the mitochondrial membrane and inhibit the activating effects of BH3-only pro-apoptotic molecules.vCyclin LANA1, LANA2, K-bZIP and RTA inhibit p53-induced apoptosis either through direct binding or through inhibition of the p300/CBP coactivator used in p53 transcriptional signaling. vIRFbinds and inhibits pro-death activities of proteins Bid and Bim. Modified from Moore P.S. et al. (2007) [164].