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. Author manuscript; available in PMC: 2013 Jun 25.
Published in final edited form as: Adv Drug Deliv Rev. 2010 Sep 29;63(7):539–546. doi: 10.1016/j.addr.2010.09.011

Figure 3.

Figure 3

(A) Transaxial PET summation images depicting radioactivity distribution in brain in one subject after administration of an iv microdose of (R)-[11C]verapamil (left image) and an iv microdose preceded by an oral therapeutic dose (1 mg/kg) of verapamil given 1 h before radiotracer injection (middle image). The right image shows the subject’s brain magnet resonance image (MRI). The radiation scale is set from 0 to 2.8 standardized uptake value (SUV). PET images were recorded on an Advance PET scanner (General Electrics Medical Systems). (B) Time-activity curves (mean SUV±SD) of (R)-[11C]verapamil in whole brain grey matter after administration of an iv microdose (open squares) and an iv microdose preceded by an oral therapeutic dose (1 mg/kg) of racemic verapamil given 1 h before radiotracer injection (filled diamonds) in 6 healthy volunteers. The chemical structure of (R)-[11C]verapamil is shown on top of the graph.