Table 3.
Cox proportional hazards analysis of MMP2 genetic interaction profiles and distant metastasis-free survival.
| Variables | n (%) | n of events | Univariate analysis | Multivariate analysis* | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |||
| MMP2 gene polymorphisms | ||||||
| Low risk | 85 (36.5) | 5 | 1.00 | 1.00 | ||
| Medium risk | 113 (48.5) | 18 | 2.79 (1.04-7.53) | 0.042 | 3.73 (1.18-11.8) | 0.025 |
| High risk | 35 (15.0) | 7 | 3.70 (1.18-11.7) | 0.025 | 3.37 (0.86-13.2) | 0.082 |
| Trend | 1.87 (1.12-3.12) | 0.017 | 1.77 (1.00-3.15) | 0.050 | ||
Abbreviations: HR, hazard ratio; CI, confidence interval; MMP, matrix metalloproteinase. *Age, gender, CEA levels, tumor differentiation, stage, lymphovascular invasion, perineural invasion, lymph node involvement, and genetic risk classification by MMP2 polymorphisms were included in the multivariate analysis. P ≤ 0.05 are in boldface.