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. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: Exp Cell Res. 2013 Mar 19;319(10):1431–1442. doi: 10.1016/j.yexcr.2013.02.017

Figure 3. MOSE cell progression leads to a decrease in substrate flux through the TCA.

Figure 3

(A) Pyruvate dehydrogenase (PDH) activity after 3 h incubation with the substrate (B) and substrate flux through TCA in MOSE cells representing progressive ovarian cancer at 3 h. (C) qPCR determination of PDHb and (D) qPCR determination of pyruvate dehydrogenase kinase 1 (PDK1), a negative regulator of PDH. (E-F) Protein levels of PDK1. Data are presented as mean ± SEM. Different from MOSE-E, #p 0.05, *p 0.01, **p 0.001.