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. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: Exp Cell Res. 2013 Mar 19;319(10):1431–1442. doi: 10.1016/j.yexcr.2013.02.017

Figure 5. Oxidative Capacity Rate is reduced in a step-wise manner during MOSE cell progression.

Figure 5

Oxidative capacity rate (OCR) was measured during an uncoupling challenge. Cellular respiration was modified by oligomycin, an ATP synthase blocker, carbonylcyanide-p-trifluoromethoxyphenyl hydrazone (FCCP), an electron transport chain uncoupler followed by rotenone, a complex one inhibitor of the electron transport chain. (A) Image of representative experiment where A is oligomycin treatment, B is FCCP treatment and C is rotenone treatment, measured over 2 h; (B) Change over base-line in OCR after FCCP treatment; (C) ATP synthesis rate as calculated by the difference between basal OCR and oligomycin blocked OCR. Data are presented as mean ± SEM. Different from MOSE-E, **p 0.001.