Table 12.

Inhibiting left ventricular remodeling of salvianolic acid B in vivo and in vitro.

Type	Cells/tissues	Effects	Reference
In vitro research	LX-2	p38 signaling pathway, cross effect from the Smad to ERK signaling pathway, synthesis of type I collagen,	Lv and Xu, 2012 [76]
	HL-60	MMP-9 CD, cardiac fibroblast migration, collagen synthesis, secretion of cytokine (ICAM, TNF-α, IL-6, and sVCAM-1), expression of VEGF.	Jiang et al., 2010 [77]
	PC12	A-beta aggregation, fibril formation, cellular toxicity of aged A-beta.	Tang and Zhang, 2011 [78]
Type	Organ/animals	Effects	Reference
In vivo research	Rat heart	Activity of MMP-9, increase the thickness of the left ventricular wall, improve the contraction of the heart, reduce cardiac fibrosis.	Wang et al., 2011 [75]

Note: MMP-9 CD: catalytic domain of MMP-9; LX-2: stellate cell lines; VCAM-1: vascular cell adhesion molecule-1; ICAM-1: intercellular adhesion molecule 1; IL: interleukin; TNF: tumor necrosis factor; MMP-9 CD: catalytic domain of MMP-9; ERK: extracellular-signal-regulated kinase; VEGF: vascular endothelial growth factor receptor.