Table 2.

Anti-platelet aggregation, anticoagulant, and antithrombotic effect of salvianolic acid B in vitro and in vivo.

Type	Cells/tissues	Effects	Reference
In vitro research	Human platelet endothelial cell	Activity of eNOS, L-arginine to L-citrulline, release of NO.	Radomski et al., 1990 [25, 26]
	Platelet	Collagen receptor α2β1.	Wu et al., 2008 [29]
Type	Organ/animals	Effects	Reference
In vivo research	Rats blood Rats blood	Induce SIPA. 20 kinds of protein expression, α2β1 integrin protein, levels of intracellular Ca2+, cytoskeleton-related proteins, cytoskeleton platelets structure.	Li et al., 2004 [28] Ma et al., 2011 [23]

Note: eNOS: endothelial nitric oxide synthase; L-arginine: left-handed arginine; SIPA: shear-induced platelet aggregation.