Table 1. Potential binding partners of Lgi proteins.
Proteins whose association with LGI proteins have been tested directly by co-immunoprecipitation or by co-localization of tagged proteins in cultured cells, are shown. References are abbreviated as follows: F06 (Fukata et al., 2006); F10 (Fukata et al., 2010); K (Kim et al., 2012); N (Nishino et al., 2010); Ok (Okabayashi and Kimura, 2010); Oz (Özkaynak et al., 2010); P (Park et al., 2008); Sa08 (Sagane et al., 2008); Sa10 (Sagane et al., 2010); Sp (Seppälä et al., 2011); T (Thomas et al., 2010); W (Owuor et al., 2009). In addition, LGI1 has been shown not to bind to ADAM12 (W), ROBO2 (F06), Stargazin (F06), NGR2(T), NGR3(T), and Kv1.1(F10). ADAM9 does not bind to LGI1 (F06, F10) or to LGI4 (N).
| Binding partner | Lgi1 | Lgi2 | Lgi3 | Lgi4 |
|---|---|---|---|---|
| ADAM11 | Weak (Sa08) | Binds (Oz) | Does not bind (Oz) | Moderate (Sa08) |
| Binds (W, F10) | Binds (Oz, N) | |||
| ADAM22 | Moderate (Sa08) | Does not bind (Oz) | Binds (Oz) | Strong (Sa08, Sa10) |
| Binds (T, W, F06; F10) | Binds (Sp) | Does not bind (F10) | Binds (Oz, N) | |
| ADAM23 | Strong (Sa08) | Does not bind (Oz) | Binds (O) | Strong (Sa08) |
| Binds (T, W, F06, F10) | Binds (Sp) | Binds (K) | Binds (Oz, N) | |
| FLOTILLIN1 | ND | ND | Binds (Ok) | ND |
| SYNTAXIN1 | ND | ND | Binds (P) | ND |
| NGR1 | Binds (T) | ND | ND | ND |