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. 2013 Jan;8(1):77–82.

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© 2013 Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

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Molecular activities of the CCN1 protein. CCN-1-induced integrin- and Wnt-dependent gene expression culminates in cell growth, adhesion and/or migration. HSPGs, heparan sulfate proteoglycans; FAK, focal adhesion kinase; MAPK, mitogen-activated protein kinase; Wnt, Wingless integration; LRP5/6, low density lipoprotein receptor-related protein 5/6; Dvl, disheveled; GSK-3b, glycogen synthase kinase 3 beta; APC, adenomatous polyposis coli; MMP-2, matrix metalloproteinase-2; VEGF, vascular endothelial growth factor Col-IV, type 4 collagen; FzD, Frizzled