Table 5. AED Dose with TCAM Outcomes: “High Dose” and “Low Dose” Subgroups for Carbamazepine, Lamotrigine and Valproate.

		TCAM Fluency	TCAM Originality
Group	N	Mean (SD)	Mean (SD)
Across Drug Exposures	42	91.9 (16.4)	97.3 (15.8)
CBZ (Median=800)
< Median	7	86.8 (11.5)	90.7 (6.5)
≥ Median	9	98.7 (19.8)	103.9 (20.6)
LTG (Median=400)
< Median	6	92.5 (8.4)	101.0 (13.5)
≥ Median	11	99.1 (15.4)	104.2 (16.0)
VPA (Median=1250)
< Median	4	83.0 (4.2)	85.5 (3.1)
≥ Median	5	71.1 (4.5)	83.2 (3.3)

To reflect differing dose ranges for each AED in this cohort and in clinical practice, median dose was calculated from reports of Total Daily Dose (TDD): lamotrigine 400 mg; carbamazepine 800 mg; and valproate 1250 mg. These median dose values were used to partition each AED group into “high dose” and “low dose” subgroups. Sample sizes in each subgroup are reported for the purpose of describing each AED’s distribution only.