Table 1.
Baseline characteristics by sex of study population by plasma cholesteryl ester transfer protein activity and phospholipid transfer protein activity.
| Cholesterol ester transfer protein activity | Phospholipid transfer protein activity | |||||
|---|---|---|---|---|---|---|
| Men (N = 1188) | ||||||
| <median N = 593 | ≥median N = 595 | P value | <median N = 611 | ≥median N = 577 | P value | |
| Age, yr | 58.0 ± 9.5 | 58.6 ± 9.7 | 0.26 | 58.1 ± 9.6 | 58.5 ± 9.6 | 0.55 |
| Body mass index, kg/m2 | 28.4 ± 4.4 | 28.7 ± 4.5 | 0.25 | 28.4 ± 4.3 | 28.8 ± 4.6 | 0.08 |
| Systolic blood pressure, mm Hg | 129.7 ± 16.8 | 130.0 ± 17.3 | 0.76 | 129.1 ± 17.1 | 130.6 ± 16.9 | 0.15 |
| Diastolic blood pressure, mm Hg | 77.9 ± 9.0 | 77.8 ± 9.3 | 0.75 | 77.6 ± 9.0 | 78.1 ± 9.3 | 0.30 |
| Blood pressure therapy, % | 26 | 27 | 0.58 | 25 | 28 | 0.29 |
| Smoking, % | 13 | 15 | 0.33 | 14 | 15 | 0.37 |
| Diabetes, % | 8 | 10 | 0.43 | 8 | 10 | 0.13 |
| HDL-C, mg/dl | 46.6 ± 13.2 | 41.0 ± 10.6 | <0.001 | 41.4 ± 11.0 | 46.3 ± 13.1 | <0.001 |
| LDL-C, mg/dl | 127.2 ± 33.2 | 128.9 ± 32.4 | 0.39 | 126.9 ± 34.3 | 129.3 ± 31.2 | 0.21 |
| Triglycerides, mg/dl | 136.3 ± 80.4 | 144.5 ± 93.4 | 0.10 | 146.7 ± 96.3 | 133.7 ± 75.8 | 0.01 |
| Lipid drug therapy, % | 11 | 10 | 0.56 | 12 | 10 | 0.45 |
| Plasma CETP activity, pmol/L/h | 41.1 ± 8.4 | 66.8 ± 12.2 | <0.001 | 54.8 ± 15.4 | 53.1 ± 17.8 | 0.08 |
| Plasma PLTP activity, pmol/L/h | 7.6 ± 3.4 | 7.0 ± 3.3 | 0.006 | 4.8 ± 1.2 | 9.9 ± 2.9 | <0.001 |
| Women (N = 1491) | ||||||
| <median N = 745 | ≥median N = 746 | P value | <median N = 763 | ≥median N = 728 | P value | |
| Age, yr | 59.1 ± 9.3 | 58.2 ± 10.0 | 0.08 | 58.4 ± 9.9 | 58.8 ± 9.4 | 0.46 |
| Body-mass index, kg/m2 | 26.9 ± 5.4 | 27.7 ± 5.9 | 0.007 | 27.2 ± 5.6 | 27.4 ± 5.6 | 0.57 |
| Systolic blood pressure, mm Hg | 126.1 ± 19.1 | 126.7 ± 20.6 | 0.57 | 125.6 ± 19.3 | 127.3 ± 20.5 | 0.09 |
| Diastolic blood pressure, mm Hg | 74.0 ± 8.7 | 73.4 ± 9.4 | 0.19 | 73.5 ± 9.0 | 74.0 ± 9.1 | 0.35 |
| Blood pressure therapy, % | 23 | 23 | 0.89 | 21 | 24 | 0.17 |
| Smoking, % | 15 | 15 | 0.89 | 15 | 14 | 0.72 |
| Diabetes, % | 7 | 7 | 0.68 | 6 | 8 | 0.39 |
| HDL-C, mg/dl | 61.2 ± 17.2 | 55.1 ± 14.7 | <0.001 | 55.4 ± 15.3 | 61.0 ± 16.8 | <0.001 |
| LDL-C, mg/dl | 126.9 ± 34.5 | 127.0 ± 34.7 | 0.98 | 128.6 ± 35.7 | 125.2 ± 33.3 | 0.06 |
| Triglycerides, mg/dl | 124.3 ± 69.9 | 134.7 ± 76.6 | 0.006 | 129.8 ± 73.5 | 129.21 ± 73.5 | 0.88 |
| Lipid drug therapy, % | 9 | 8 | 0.78 | 9 | 8 | 0.27 |
| Estrogen Treatment, % | 26% | 28% | 0.31 | 25% | 30% | 0.05 |
| Plasma CETP activity, pmol/L/h | 45.4 ± 9.1 | 71.9 ± 12.4 | <0.001 | 59.7 ± 16.8 | 57.6 ± 17.5 | 0.02 |
| Plasma PLTP activity, pmol/L/h | 8.8 ± 3.9 | 8.7 ± 3.7 | 0.56 | 5.9 ± 1.51 | 11.7 ± 3.2 | <0.001 |
Data are means ± SD unless indicated; Median values of CETP activity for men 52.7 pmol/L/h, for women 57.6 pmol/L/h; Median values of PLTP activity for men 6.8 pmol/L/h, for women 8.2 pmol/L/h.