Table 3.

Association of plasma CETP activity and PLTP activity with incidence of CVD events by sex: results of multivariable Cox regression.

Model	Men		Women
	Hazards ratio (95% CI)	P	Hazards ratio (95% CI)	P
Plasma CETPb as a continuous variable, adjusted for baseline risk factorsa	0.79 (0.64, 0.98)	0.032	1.01 (0.81, 1.27)	0.914
Plasma CETPb as a continuous variable, adjusted for baseline risk factorsa and PLTP	0.80 (0.65, 0.99)	0.036	1.01 (0.81, 1.27)	0.920
Plasma CETP activity as a binary variable, adjusted for baseline risk factorsa and PLTP; hazards ratio for CETP activity ≥median (<median as referent)	0.64 (0.43, 0.95)	0.026	0.94 (0.59, 1.49)	0.789
Plasma PLTPb as a continuous variable, adjusted for baseline risk factorsa	1.20 (1.00, 1.45)	0.046	1.03 (0.81, 1.32)	0.796
Plasma PLTPb as a continuous variable, adjusted for baseline risk factorsa and CETP	1.20 (1.00, 1.44)	0.052	1.03 (0.81, 1.32)	0.799
Plasma PLTP activity as a binary variable, adjusted for baseline risk factorsa and CETP; Hazards Ratio for CETP activity ≥median (<median as referent)	1.64 (1.10, 2.46)	0.016	0.95 (0.60, 1.51)	0.838
CETP/PLTP activity ratiob	0.66 (0.51, 0.87)	0.003	0.97 (0.75, 1.25)	0.806

^aAdjustments: age, smoking, diabetes, obesity (defined as BMI ≥ 30), systolic blood pressure, use of antihypertensive medications, plasma HDL-C, triglycerides, and LDL-C.

^bHazard ratio is per 1 standard deviation.