Figure 2.

¹¹C-PBR28 binding was related to early age of onset in Alzheimer’s disease (AD). (A) Early-onset (EOAD) patients had greater binding than late-onset patients (LOAD). Bar graphs show values for ¹¹C-PBR28 binding (V_T / f_P) in inferior parietal lobule, corrected for partial volume effect. ¹¹C-PBR28 binding values were adjusted for TSPO genotype, Mini-Mental State Examination score, and duration of symptoms. Error bars denote SD. (B) ¹¹C-PBR28 binding negatively correlated with age of symptom onset in patients with Alzheimer’s disease and MCI. ¹¹C-PBR28 binding values from inferior parietal lobule, corrected for partial volume effect, and age of onset were adjusted for TSPO genotype, Mini-Mental State Examination score, and duration of symptoms before correlative analysis. Standardized adjusted values are shown. Correlation coefficient (r) = −0.438, P = 0.017.