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Validation of SGAtools performance. (a and b) Comparison of simulated colony sizes (x-axis) with ones subject to confounding experimental effects (y-axis) before (a, r = 0.42) and after (b, r = 0.66) SGAtools normalization. (c) Comparison of SGAtools interaction score (x-axis) with gold standard based on Costanzo et al. [(9), y-axis, r = 0.70].
