FIG. 2.

Ontogeny of Gag CM9 escape and associated substitutions. Predicted amino acid sequences are shown for the region surrounding the Gag CM9 epitope in five Mamu-A*01-positive animals infected with SIVmac239. Plasma virus RNA was isolated, reverse transcribed, and directly sequenced as described for Fig. 1. Lowercase letters indicate the amino acid encoded by the variant codon at sites of mixed-base nucleotide heterogeneity.