Table 1.

Table Patient Characteristics

Patient No./Sex/ Age at Onset, y/Symptom Duration, y	Pertinent Medical History	Previous Ineffective Therapies	Therapies With at Least Partial Efficacy
1/F/38/9	Depression, chronic pain, cervical stenosis, fibromyalgia, migraines, essential tremor, Raynaud phenomenon	Topical steroids, topical clindamycin	Gabapentin, combination cream of ketamine, 15%/amitriptyline, 5%/clonidine, 0.2%/ketoprofen, 10%
2/F/45/15	Depression, migraines	Topical capsaicin, pregabalin, tramadol	Gabapentin, duloxetine
3/F/25/10	Acne vulgaris, migraines, allergic contact dermatitis	Oral tetracyclines, topical metronidazole, nadolol, gabapentin, amitriptyline	Amoxicillin, desonide for itch
4/F/50/10	Carpal tunnel syndrome, autoimmune thyroiditis, chronic pain, neurogenic itch, spondylolisthesis	NA	Gabapentin, duloxetine
5/F/36/8	Complex regional pain syndrome, positive ANA without other known autoimmune disease	Oral antibiotics, topical steroids	Pregabalin, duloxetine
6/F/29/8	Mixed connective tissue disease, Raynaud phenomenon, depression, bulimia	Topical metronidazole, hydroxychloroquine	Gabapentin, minocycline
7/M/37/13	Scrotal dysesthesia, psoriasis, C3–6 degenerative joint disease	Topical metronidazole	Minocycline, doxycycline
8/F/41/17	Rheumatoid arthritis	Topical metronidazole, topical steroids, oral antibiotics, β-blockers, gabapentin, hydroxychloroquine, amitriptyline	Nortriptyline
9/M/15/10	Psoriatic arthritis, irritable bowel syndrome, obsessive compulsive disorder	Topical metronidazole, topical steroids, gabapentin, topiramate, botulinum toxin type A, laser therapy, thoracic sympathectomy, clonidine, propranolol	Topical glycopyrrolate, 3%; prazosin, memantine NMDA-receptor antagonist
10/F/53/5	Oral lichen planus, headaches	Topical sulfa	Amoxicillin
11/F/32/12	Headaches	Topical metronidazole, topical steroids, gabapentin, pregabalin	Topical capsaicin, duloxetine
12/F/60/2	Complex regional pain syndrome, Raynaud phenomenon, depression, esophageal dysmotility, positive ANA without other known autoimmune disease	Topical metronidazole, topical steroids, topical doxepin	Gabapentin, hydroxychloroquine
13/F/37/8	Anxiety, depression, headaches, Raynaud phenomenon	Topical sulfasalazine, topical metronidazole, azelaic acid, doxycycline, gabapentin, intense pulsed light, topical amitriptyline, topical ketamine	Titanium dioxide, hydroxychloroquine, amitriptyline, propranolol
14/F/22/9	Systemic lupus erythematosus, Raynaud phenomenon	Topical metronidazole, oral tetracyclines, gabapentin, pregabalin, β-blockers, vascular laser therapy, topical doxepin, topical ketamine	Hydroxychloroquine, memantine

Abbreviations: ANA, antinuclear antibody; NA, not applicable; NMDA, N-methyl-D-aspartic acid.