Table 2.

Proportion Achieving Response and Remission From Baseline BSI-12 Score^a

	MDD at Baseline			No MDD at Baseline
	CALM	Usual Care		CALM	Usual Care
	Proportion (95% CI)	Proportion (95% CI)	p value	Proportion (95% CI)	Proportion (95% CI)	p value
Response b
6 mo	0.56(0.50 to 0.61)	0.32(0.26 to 0.38)	<.001	0.62(0.54 to 0.69)	0.44(0.37 to 0.52)	0.002
12 mo	0.63(0.57 to 0.69)	0.41(0.35 to 0.47)	<.001	0.66(0.57 to 0.73)	0.50(0.42 to 0.58)	0.009
18 mo	0.64(0.58 to 0.70)	0.46(0.40 to 0.52)	<.001	0.67(0.59 to 0.75)	0.60(0.52 to 0.68)	0.236
Remission c
6 mo	0.41(0.35 to 0.47)	0.20(0.15 to 0.25)	<.001	0.48(0.41 to 0.56)	0.39(0.31 to 0.47)	0.087
12 mo	0.50(0.44 to 0.56)	0.26(0.21 to 0.32)	<.001	0.55(0.47 to 0.63)	0.43(0.35 to 0.51)	0.040
18 mo	0.50(0.43 to 0.56)	0.28(0.22 to 0.34)	<.001	0.55(0.46 to 0.63)	0.50(0.42 to 0.58)	0.421

Abbreviations: BSI-12 = 12-item version of Brief Symptom Inventory (Anxiety + Somatization Subscales). MDD = Major Depressive Disorder. CI = confidence interval.

^aData presented as proportion weighted for non-response at each follow-up.

^bResponse defined as ≥ 50% reduction on the BSI-12, with all those in remission considered to have responded; 95% CI in parentheses.

^cRemission defined as a per item BSI-12 score of <0.5 (total score <6); 95% CI in parentheses.