Table 2.
Frequencies of statin-related events among study patients
| Statin-related event category | Patients (%) |
|---|---|
| Myalgia or myopathy | 5075 (4.7) |
| Rhabdomyolysis | 7 (0.006) |
| CK 3-10 ULN | 992 (0.9) |
| Musculoskeletal and connective tissue disorders other than myalgia or myopathy | 2742 (2.5) |
| Muscle spasms | 882 (0.8) |
| Pain in extremity | 537 (0.5) |
| Arthralgia | 356 (0.3) |
| Other | 967 (0.9) |
| General disorders and administration site conditions | 2493 (2.3) |
| Pain | 1222 (1.1) |
| Fatigue | 313 (0.3) |
| Asthenia | 208 (0.2) |
| Other | 750 (0.7) |
| Hepatobiliary disorders | 2308 (2.1) |
| Drug intolerant | 1827 (1.7) |
| Gastrointestinal disorders | 1681 (1.6) |
| Nervous system disorders | 564 (0.5) |
| Memory problems | 70 (0.06) |
| Immune system disorders | 399 (0.4) |
| Vascular disorders | 399 (0.4) |
| Psychiatric disorders | 333 (0.3) |
| Unknown | 246 (0.2) |
| Cardiac disorders | 133 (0.1) |
| Injury, poisoning and procedural complications | 112 (0.1) |
| Skin and subcutaneous tissue disorders | 107 (0.1) |
| Reproductive system and breast disorders | 99 (0.09) |
| Respiratory, thoracic and mediastinal disorders | 82 (0.08) |
| Drug ineffective | 50 (0.05) |
| Ear and labyrinth disorders | 35 (0.03) |
| Blood and lymphatic system disorders | 34 (0.03) |
| Renal and urinary disorders | 23 (0.02) |
| Eye disorders | 20 (0.02) |
| Metabolism and nutrition disorders | 16 (0.01) |
Number of patients with statin-related events among all 107,835 patients included in the study. Statin-related events were classified according to the Medical Dictionary for Regulatory Activities (MedDRA).
Abbreviations: CK, creatine kinase; ULN, upper limit of normal.