Figure 2.

Disproportionate upregulation of testis-specific genes in males with resistant Y chromosomes. Genes differentially expressed in D. simulans were clustered based on the D. melanogaster FlyAtlas tissue expression data (Chintapalli et al., 2007). Panels show the distribution of differentially expressed genes across 11 adult tissues. Expression levels were normalized for each gene with light and dark denoting high and low transcript abundance, respectively. (a) 409 genes that were upregulated and (b) 436 genes that were downregulated in the resistant Y chromosome males as contrasted to the control SR1227 males. Similarly, (c) 233 genes were upregulated and (d) 288 genes were downregulated in the resistant Y males as contrasted to the sensitive Y males.