Table 2.
Creatine kinase and degree of muscle rigidity in 24 cases of neuroleptic malignant syndrome
| Case | Serum CK (IU/L)
|
Muscle rigidity
|
|||||
|---|---|---|---|---|---|---|---|
| Max value | The first day of increased CK (day) | Peak day of CK (day) | Number of measurement of CK (times) | Existence before fever onset (evaluation) | Appearance day (day) | Peak evaluation | |
| 1 | 722 | 2 | 3 | 9 | −/(0) | 8 | 3 |
| 2 | 1277 | 2 | 2 | 12 | −/(0) | 4 | 3 |
| 3 | 1236 | 4 | 8 | 8 | +/(1) | Before onset of fever | 3 |
| 4 | 2890 | 1 | 6 | 13 | +/(1) | Before onset of fever | 3 |
| 5 | 3854 | 3 | 3 | 6 | +/(1) | Before onset of fever | 3 |
| 6 | 495 | 2 | 2 | 8 | −/(0) | 3 | 3 |
| 7 | 3180 | 2 | 2 | 7 | +/(1) | Before onset of fever | 2 |
| 8 | 10,190 | 1 | 6 | 6 | +/(1) | Before onset of fever | 3 |
| 9 | 887 | 5 | 5 | 6 | −/(0) | 5 | 2 |
| 10 | 9580 | 1 | 1 | 8 | +/(1) | Before onset of fever | 3 |
| 11 | 1688 | 1 | 8 | 8 | +/(1) | Before onset of fever | 3 |
| 12 | 44,880 | 2 | 2 | 7 | +/(1) | Before onset of fever | 3 |
| 13 | 22423 | 1 | 2 | 9 | +/(1) | Before onset of fever | 3 |
| 14 | 1558 | 3 | 4 | 5 | −/(0) | 2 | 2 |
| 15 | 2238 | 1 | 10 | 6 | +/(1) | Before onset of fever | 3 |
| 16 | 777 | 5 | 5 | 7 | +/(2) | Before onset of fever | 3 |
| 17 | 7346 | 3 | 3 | 7 | +/(1) | Before onset of fever | 3 |
| 18 | 772 | 2 | 2 | 6 | +/(1) | Before onset of fever | 3 |
| 19 | 9610 | 4 | 9 | 5 | −/(0) | 7 | 2 |
| 20 | 1426 | 1 | 5 | 8 | +/(2) | Before onset of fever | 3 |
| 21 | 3949 | 1 | 2 | 5 | +/(1) | Before onset of fever | 3 |
| 22 | 839 | 4 | 4 | 4 | +/(1) | Before onset of fever | 3 |
| 23 | 2755 | 1 | 7 | 11 | +/(1) | Before onset of fever | 3 |
| 24 | 4273 | 4 | 4 | 6 | −/(0) | 12 | 3 |
Note: The degree of muscle rigidity was evaluated using the NMS scale proposed by Sachdev.15
Abbreviations: CK, creatine kinase; NMS, neuroleptic malignant syndrome.