Table 3.
Temporal changes in body temperature, serum creatine kinase, and muscle rigidity in 24 cases of neuroleptic malignant syndrome
| Body temperature | Serum CK | Evaluation of muscle rigidity | |
|---|---|---|---|
| Before fever onset (Day −3 and Day −7) | 36.6 ± 0.5 (n = 20) | – | Day −10.78 ± 0.58 (n = 24) |
| Day 1 | 38.2 ± 0.7* (n = 24) | 1414 ± 2675 (n = 11) | 1.00 ± 0.88 (n = 24) |
| Day 2 | 38.2 ± 0.7* (n = 24) | 7853 ± 13,256** (n = 11) | 1.39 ± 1.05 (n = 24) |
| Day 3 | 38.1 ± 0.9* (n = 24) | 4773 ± 6271 (n = 13) | 1.65 ± 1.12* (n = 24) |
| Day 4 | 38.1 ± 0.8* (n = 24) | 1795 ± 2715 (n = 14) | 1.91 ± 1.05* (n = 24) |
| Day 5 | 37.8 ± 0.9* (n = 23) | 1191 ± 1895 (n = 12) | 1.78 ± 0.97* (n = 24) |
| Day 6 | 37.7 ± 0.7* (n = 24) | 2023 ± 2798 (n = 11) | 1.69 ± 1.08* (n = 24) |
| Day 7 | 37.5 ± 0.6* (n = 23) | 938 ± 1106 (n = 11) | 1.56 ± 1.05* (n = 24) |
| Day 8 | 37.7 ± 0.7* (n = 23) | 1502 ± 1977 (n = 13) | 1.52 ± 0.92* (n = 24) |
| Day 9 | 37.7 ± 0.9* (n = 24) | 959 ± 2411 (n = 14) | 1.17 ± 0.91* (n = 24) |
| Day 10 | 37.6 ± 0.8* (n = 23) | 693 ± 788 (n = 5) | 1.08 ± 0.92 (n = 24) |
| Day 11 | 37.5 ± 0.8* (n = 21) | 380 ± 446 (n = 10) | 1.04 ± 1.04 (n = 24) |
| Day 12 | 37.5 ± 0.9* (n = 21) | 165 ± 92 (n = 9) | 0.78 ± 1.01 (n = 24) |
| – | – | – | – |
| After recovery | 36.8 ± 0.3 (n = 23) | 104 ± 71 (n = 23) | 0.14 ± 0.46 (n = 23) |
Notes: Data are expressed as mean ± SD values. Data are shown until day 12 from the onset of fever because mean serum creatine kinase was normalized on day 12 (normal range 46–210 IU/L). Statistically significant differences are indicated as follows:
*
P < 0.05 (versus before fever onset);
**
P = 0.007 (versus after recovery).
Abbreviations: CK, creatine kinase; SD, standard deviation.