Table 7.
Affinity of substituted methcathinones and standard compounds at hSigma1 receptors.
| Drug | Inhibition of [3H]pentazocine binding Ki ± sem (µM) (n) |
|---|---|
| Butylone | 7.9 ± 1.8 (7) |
| 4-FMC | 24.2 ± 9.0 (5) |
| MDPV | 4.4 ± 1.7 (6) |
| Mephedrone | 7.8 ± 2.0 (6) |
| Methylone | 25.5 ± 7.7 (6) |
| Naphyrone | 0.509 ± 0.052 (6) |
| METH | 3.18 ± 0.74 (9) |
| MDMA | 19.4 ± 6.3 (3) |
| Methcathinone | 117 ± 40 (3) |
| Haloperidol | 0.00094 ± 0.00039 (6) |
| Spiperone | 1.31 ± 0.24 (5) |
(n) Number of independent experiments conducted in duplicate.
Hill slopes for [3H]pentazocine binding ranged from −0.68 to −1.23.