Figure 4. Layered signaling regulatory networks driven by co-differently-expressed microarray genes involved in malignant transition of colorectal cancer from the benign chronic non-solving ulcerative colitis to the more aggressive one.

In the layered signaling regulatory networks, the size of each node was proportional to the degree. In addition, red, blue and green represented nodes stemmed from signaling networks 3, 6 and 7, respectively.