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. 2013 Jun 25;8(6):e66420. doi: 10.1371/journal.pone.0066420

Figure 4. Both vaccines of rR32 and hR32 decreased SBP and PRA of SHRs.

Figure 4

A. The antibody titers of the rR32 and hR32 vaccines. B. The rR32 and hR32 vaccines significantly decreased SBP of SHRs compared with the KLH immunization group. During the whole experiment, SBP of the valsartan group was significantly lower than that of the control group. C. On week 12, the PRA of the rR32 and hR32 groups was decreased compared with the control group, while the PRA of the valsartan group was increased. D. Ang II concentration in the vaccine groups tend to be lower than that of the control group, but no significance was observed. The Ang II concentration in the valsartan group was increased. *P<0.05 presents the vaccines groups vs the control group, and #P<0.01 presents the valsartan group vs the control group.