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. 2013 Jun 25;8(6):e66227. doi: 10.1371/journal.pone.0066227

Table 1. Characteristics of association studies eligible for inclusion in Meta-Analysis of 5-HTTLPR polymorphisms and Post-traumatic Stress Disorder (PTSD).

First author Year Study design PTSD N Controls N Total sample (N) Males N (%) MeanAge Diagnostic instrument PTSD assessed Biallelic/ Triallelic Genotype GxE study Interaction description Remarks
Lee [18] 2005 Case-Control 100 197 297 119 (40.1) 34.94 SCID-I Korean Version Current Biallelic No - Included
Koenen [16] 2009 Cross-Sectional 19 571 590 215 (36.4) 65.1 National Women's Study PTSD Module Last 6 months Triallelic Yes High crime & High unemployment rate Included
Mellman [21] 2009 Case-Control 55 63 118 40 (33.9) 39.97 CAPS Lifetime Triallelic No - Included
Xie [20] 2009 Cross-Sectional 229 1023 1252 656 (52.4) 38.97 SSADDA Lifetime Triallelic Yes Childhood adversity & Adult traumatic events Included
Grabe [19] 2009 Cross-Sectional 67 1596 1663 857 (51.5) 57.61 PTSD Module of SCID Lifetime Triallelic Yes Frequent Trauma event Included
Thakur [47] 2009 Cohort study 24 17 41 19 (46.3) 31.96 CAPS Last year Biallelic No Included
King [52] 2009 Cohort study 378 Computer-aided telephone interviews. Lifetime Triallelic Yes Childhood adversity Not included
Kolassa [17] 2010 Cross-Sectional 331 77 408 218 (53.4) 34.72 Post-traumatic Diagnostic Scale Lifetime Biallelic Yes Number of traumatic events experienced Included
Handwerger [53] 2010 Case-Control 18 18 36 No Not included
Saying [48] 2010 Cohort study 29 48 77 47 (61) CAPS Lifetime Biallelic No Included
Koenen [50] 2011 Cross-Sectional 23 77 100 40 (40) 45.32 Modified PTSD Checklist Lifetime Triallelic Yes Number of traumatic events Included
Morey [49] 2011 Case-Control 22 20 42 22 (52.4) 34.04 DTS. Cutoff score  =  32 Current Triallelic No Included
Valente [46] 2011 Case-Control 65 34 99 28 (28.3) 39.99 SCID-I & CAPS Current Biallelic No Included
Wang [45] 2011 Case-Control 212 176 388 200 (51.55) 49.06 SCID-I, MINI, CES y CAPS Current Triallelic No Included
King [44] 2011 Case-Control 16 14 30 Biallelic No Not included
Xie [51] 2012 Cross- Sectional AA 321 2078 2399 1343 (56) 42.2 SSADDA Lifetime Biallelic Yes Childhood adversity Included
EA 398 2381 2779 1559 (56.1) 39

GxE study: Gene-Environmental interaction study; SCID-1: Structured Clincal Interview for DSM-IV; CAPS: Clinical Assessed PTSD Scale; SSADDA: Semi-Structured Assessment for Drug Dependence and Alcoholism; MINI: Mini-International Neuropsychiatric Interview; CES: Combat Exposure Scale; DTS: Davidson Trauma Scale; AA: Afro-Americans; EA: Euro-Americans.