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. 2013 Jun 25;8(6):e66227. doi: 10.1371/journal.pone.0066227

Table 2. Frequencies of the 5-HTTLPR alleles and polymorphisms of the included studies&.

Biallelic genotype approach HWE Triallelic genotype approach HWE
PTSD Controls P-value PTSD Controls P-value
S L SS SL LL S L SS SL LL S' L' S'S' S'L' L'L' S’ L' SvS' S'Lv LvL'
Lee [18] 2005 175 25 77 21 2 319 75 129 61 7 0.81
Koenen [16] 2009 17 21 4 9 6 539 603 116 307 148 0.06
Mellman [21 2009 42 70 5 32 19 35 93 7 21 36 0.16 66 46 20 26 10 67 61 18 31 15 0.81
Xie [20] 2009 234 224 58 118 53 957 1089 234 489 300 0.20
Grabe [19] 2009 40 94 6 28 33 1294 1898 264 766 566 0.86 48 86 8 32 27 1512 1680 364 784 448 0.55
Thakur [47] 2009 23 25 8 7 9 22 12 7 8 2 0.09
Kolassa [17] 2010 112 550 15 82 234 29 125 1 27 49 0.20
Saying [48] 2010 30 28 6 18 5 41 55 6 29 13 0.045
Koenen [50] 2011 10 34 1 8 13 45 103 12 21 41 0.005 21 23 4 13 5 67 81 17 33 24 0.39
Morey [49] 2011 22 22 7 8 7 18 22 3 12 5 0.34 26 18 10 6 6 22 18 5 12 3 0.34
Valente [46] 2011 55 71 13 29 21 38 30 9 20 5 0.26
Wang [45] 2011 207 217 56 95 61 131 221 21 89 66 0.28 261 163 94 73 45 164 188 29 106 41 0.005
Xie (AA) [51] 2012 222 650 26 170 240 1269 3997 170 929 1534 0.07
Xie (EA) [51] 2012 460 564 96 268 148 2511 3187 566 1379 904 0.34

S, short allele; L, long allele; S' as S + LG; and L' as LA.

&

Dominant model (S+ vs LL or S'+vs L'L'): S+ (or S'+) genotype frequencies are calculated as the sum of SS (or S'S') and SL (or S'L') frequencies. Recessive model (SS vs L+ or S'S' vs L'+): L+ (or L'+) genotype frequencies are calculated by the sum of LL (or L'L') and SL (or SvL') genotype frequencies.