Skip to main content
. 2013 Jun 25;8(6):e66967. doi: 10.1371/journal.pone.0066967

Table 1. Comparison of the in vivo potency of a set antimalarial drugs in the ED90-normalized assay versus the Peters' 4-day test.

Compound ED90-normalized assay Peters' 4-day test
Atovaquone 0.4 (0.2–0.6) 0.06 (0.05–0.06)
Pyrimethamine 0.8 (1.2–1.6) 0.2 (0.1–0.4)
GSK932121 2.1 (1.0–3.0) 0.3 (0.26–0.4)
Mefloquine 4.2 (3.3–5.2) 2.0 (1.6–2.3)
Amodiaquine 5.1 (4–6.5) 3.2 (3.0–3.5)
Chloroquine 6.1 (3.9–7.5) 3.1 (2.8–3.5)
Artesunate 6.8 (6.0–7.5) 7.9 (7.4–8.3)
Piperaquine 7.8 (4.5–11.0) 4.2 (3.2–8.3)
Quinine 114.5 (78.7–166.3) 92.5 (81.3–110)
Pentamidine >80.0 >40.0
Azithromycin >200.0 13.0 (12.2–14.1)
Doxicycline >300.0 170.8 (141.1–209.1)

Data are mean (95% CI).