Table 1. Comparison of the in vivo potency of a set antimalarial drugs in the ED90-normalized assay versus the Peters' 4-day test.
Compound | ED90-normalized assay | Peters' 4-day test |
Atovaquone | 0.4 (0.2–0.6) | 0.06 (0.05–0.06) |
Pyrimethamine | 0.8 (1.2–1.6) | 0.2 (0.1–0.4) |
GSK932121 | 2.1 (1.0–3.0) | 0.3 (0.26–0.4) |
Mefloquine | 4.2 (3.3–5.2) | 2.0 (1.6–2.3) |
Amodiaquine | 5.1 (4–6.5) | 3.2 (3.0–3.5) |
Chloroquine | 6.1 (3.9–7.5) | 3.1 (2.8–3.5) |
Artesunate | 6.8 (6.0–7.5) | 7.9 (7.4–8.3) |
Piperaquine | 7.8 (4.5–11.0) | 4.2 (3.2–8.3) |
Quinine | 114.5 (78.7–166.3) | 92.5 (81.3–110) |
Pentamidine | >80.0 | >40.0 |
Azithromycin | >200.0 | 13.0 (12.2–14.1) |
Doxicycline | >300.0 | 170.8 (141.1–209.1) |
Data are mean (95% CI).