Table 1. Virulence gene profile of a MRSA isolate from the neonatal outbreak (Mette Theilgaard Christiansen, personal communication).
Virulence factors | Relatedgenes | Nucleotidehomology | Virulence factors | Relatedgenes | Nucleotidehomology | Virulence factors | Relatedgenes | Nucleotidehomology |
Adherence | Exoenzyme | Toxin | ||||||
Autolysin | atl | 100.00% | Cysteine protease | sspB | 100.00% | Beta hemolysin | hlb | 100.00% |
Cell wall associated fibronectin binding protein | ebh | 93.57% | sspC | 99.70% | Delta hemolysin | hld | 100.00% | |
Clumping factor B | clfB | 92.61% | Hyaluronate lyase | hysA | 100.00% | Exfoliative toxin type A | eta | 99.47% |
Collagen adhesion | cna | 98.51% | Lipase | lip | 100.00% | Exotoxin/superantigen-like proteins | set2 | 100.00% |
Extracellular adherence protein/MHC analogous protein | eap/map | 92.92% | geh | 100.00% | set3 | 100.00% | ||
Fibronectin binding proteins | fnbA | 97.93% | Serine protease | splA | 100.00% | set4 | 100.00% | |
fnbB | 100.00% | splB | 100.00% | set16 | 100.00% | |||
Intercellular adhesin | icaR | 100.00% | splD | 100.00% | set17 | 100.00% | ||
icaA | 100.00% | splE | 100.00% | set18 | 100.00% | |||
icaD | 100.00% | splF | 100.00% | set20 | 100.00% | |||
icaB | 100.00% | Serine V8 protease | sspA | 97.78% | set21 | 100.00% | ||
icaC | 100.00% | Staphylokinase | sak | 100.00% | set22 | 100.00% | ||
Ser-Asp rich fibrinogen-binding proteins | sdrC | 92.14% | Thermonuclease | nuc | 100.00% | set23 | 99.86% | |
sdrD | 96.77% | Secretion system | set24 | 100.00% | ||||
sdrE | 100.00% | Type VII secretion system | esxA | 100.00% | set25 | 100.00% | ||
sdrH | 97.11% | esaA | 100.00% | set26 | 100.00% | |||
Staphylococcal protein A | spa | 99.11% | essA | 100.00% | hlgA | 100.00% | ||
von Willebrand factor | vwb | 99.93% | esaB | 100.00% | hlgC | 100.00% | ||
Host Immune evasion | essB | 100.00% | hlgB | 100.00% | ||||
Exoprotein SCIN | scn | 99.72% | essC | 100.00% | lukD | 100.00% | ||
Capsule Type 1, 5 and 8 | capA | 100.00% | esaC | 98.99% | lukE | 100.00% | ||
capB | 100.00% | esxB | 99.37% | |||||
capC | 100.00% | |||||||
capD | 100.00% | |||||||
capP | 99.15% |