Table 3. Haplotype association with chronicity and clearance of HBV infection, with the most common haplotype, CGG, as the reference.
Haplotype | HBV carriers (%) | Non-HBV infected subjects (%) | HBV Clearance subjects (%) | OR (95% CI)* | p* | OR (95% CI)† | p† |
CGG | 597 (59.7%) | 256 (52.2%) | 256 (49.6%) | 1 | – | 1 | – |
TAT | 147 (14.7%) | 106 (21.6%) | 108 (20.9%) | 0.62 (0.45–0.86) | 0.0044 | 1.64 (1.21–2.24) | 0.0013 |
CAT | 80 (8%) | 49 (10%) | 66 (12.8%) | 0.70 (0.45–1.09) | 0.116 | 1.98 (1.35–2.90) | 0.00041 |
CGT | 102 (10.2%) | 41 (8.4%) | 50 (9.7%) | 1.15 (0.76–1.74) | 0.495 | 1.07 (0.74–1.56) | 0.458 |
TGG | 53 (5.3%) | 28 (5.7%) | 30 (5.8%) | 0.70 (0.42–1.17) | 0.177 | 1.31 (0.80–2.13) | 0.213 |
All logistic regression analyses were adjusted for age and sex.
SNP order of haplotype: rs3077, rs9277378, rs3128917.
HBV carriers vs. non-HBV infected subjects.
Clearance subjects vs. HBV carriers.