Table 2.
Association results for the 15 SNPs investigated in this study with SCD
| Chr | SNP | Gene | BP | A1 | MAF | OR | 95% CI | *P |
|---|---|---|---|---|---|---|---|---|
| 1 | rs6675281 | DISC1 | 230020724 | T | 0.15 | 0.97 | (0.72-1.31) | 0.8618 |
| 1 | rs1130183 | KCNJ10 | 158278136 | A | 0.07 | 1.12 | (0.73-1.73) | 0.5907 |
| 2 | rs1344706 | ZNF804A | 185486673 | C | 0.39 | 1.00 | (0.80-1.25) | 0.9936 |
| 2 | rs4673628 | ERBB4 | 213387139 | A | 0.47 | 0.87 | (0.71-1.06) | 0.17 |
| 2 | rs1026882 | ERBB4 | 213387139 | C | 0.45 | 0.90 | (0.72-1.13) | 0.38 |
| 6 | rs13194053 |
Near to HIST1H2A |
27251862 | C | 0.15 | 0.81 | (0.60-1.10) | 0.1944 |
| 6 | rs3131296 | NOTCH4 | 32280971 | T | 0.11 | 0.80 | (0.57-1.12) | 0.2023 |
| 8 | rs10503929 | NRG1 | 32733525 | C | 0.22 | 1.94 | (1.50-2.50) | 2.84E-07 |
| 8 | rs3924999 | NRG1 | 32453108 | A | 0.39 | 1.02 | (0.80-1.29) | 0.85 |
| 9 | rs7045881 | PLAA | 26925996 | T | 0.10 | 1.42 | (0.99-2.06) | 0.05797 |
| 10 | rs10761482 | ANK3 | 61755343 | T | 0.22 | 0.86 | (0.66-1.12) | 0.2673 |
| 11 | rs6265 | BDNF | 27636492 | T | 0.19 | 1.29 | (0.99-1.70) | 0.05848 |
| 11 | rs12807809 |
Near to NRGN |
124111495 | C | 0.15 | 0.93 | (0.69-1.25) | 0.6364 |
| 12 | rs1006737 | CACNA1C | 2215556 | A | 0.33 | 1.11 | (0.88-1.40) | 0.3697 |
| 20 | rs1801545 | KCNQ2 | 61516722 | C | 0.085 | 1.10 | (0.74-1.64) | 0.6192 |
Chr, chromosome; BP, base pairs; A1, minor allele, MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; *P, p-value for the additive genetic model of inheritance.