Table 1. Kinetic analyses of the cellular infiltration following MHC class I Abs administration in the alloimmune murine OAD model (n=5).
| Cellular Infiltration % | Day 7 | Day 15 | Day 30 | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Class I | Isotype | Class I | Isotype | Class I | Isotype | |
|
| ||||||
| Neutrophils | 33.1±5.6% | 2.7±0.8% | 29.6±5.1% | 1.9±0.5% | 23.4±6.3% | 4.1±1.3% |
| Macrophages | 12.3±1.9% | 1.8±0.6% | 11.7±2.3% | 2.1±0.5% | 8.9±1.7% | 2.3±1.2% |
| CD8 T cells | 2.2±0.7% | 2.1±0.6% | 10.3±1.9% | 3.7±1.2% | 12.3±3.1% | 4.5±2.3% |
| CD4 T cells | 3.1±0.9% | 2.2±0.4% | 7.2±2.3% | 6.5±1.7% | 32.2±7.1% | 8.2±3.1% |
| B-cells | 1.2±0.5% | 0.9±0.5% | 1.6±0.7% | 0.9±0.3% | 14.3±3.2% | 2.1±0.9% |
|
Epi/Endothelial
cells |
48.1±9.1% | 90.3±5.1% | 39.6±12.5% | 84.9±6.7% | 10.9±8.9% | 78.8±7.9% |
|
| ||||||
| Total | 100 % | 100% | 100% | 100% | 100% | 100% |