Table 2.
Study | Materials | Participants, propranolol:placebo | Sex, % | Age, mean (SD) [range] yr | Study protocol | Outcome measures | |
---|---|---|---|---|---|---|---|
| |||||||
Male | Female | ||||||
Miller et al., unpublished* | Differential fear conditioning | 42:25 | 50 | 50 | 25 (4.2) | Day 1: learning Day 2: propanolol 5 min after reactivation Day 3: LTM test |
Skin conductance response to conditioned stimulus during extinction day 3 |
de Quervain et al.45 | Emotionally valenced word list crossover design | 14:14 | 50 | 50 | 23.9 (2.9) | Day 1: learning Day 2: 40 mg 60 min before LTM test, 2nd LTM test 2 wk later |
Free recall number of words |
Kindt et al.46* | Differential fear conditioning | 40:20 | 28 | 72 | 20.7 (2.4) | Day 1: learning; Day 2: 40 mg 90 min before memory reactivation Day 3: LTM test |
Fear potentiated startle to conditioned stimulus during extinction day 3 |
Tollenaar et al.47 | Emotionally valenced word list | 27:26 | 100 | 20.6 (2.1) | Wk 1: learning Wk 2: 80 mg 75 min before memory task Wk 3: memory task |
% recognition nouns week 3 | |
Tollenaar et al.34 | Script-driven imagery | 27:26 | 100 | 20.7 (2.2) | Wk 1: script preparation Wk 2: 80 mg 90 min before memory reactivation Wk 3: Heart rate and skin conductance response to emotional script |
Heart rate and skin conductance response week 3 | |
Soeter et al.48* | Differential fear conditioning | 40:20 | 25 | 75 | 20.4 (3.8) | Day 1: learning Day 2: 40 mg 90 min before reactivation Day 3: LTM test |
Fear potentiated startle to conditioned stimulus during extinction day 3 |
Kroes et al.49 | Emotionally valenced word list | 12:12 | 58 | 42 | 24.4 | Day 1: learning Day 2: 40 mg 90 min before reactivation Day 3: LTM test |
% free recall day 3 |
Schwabe et al.22 | Emotionally valenced pictures | 13:13 | 50 | 50 | [18–30] | Day 1: learning Day 2: 40 mg 90 min before reactivation Day 3: LTM test |
% recognition pictures day 3 |