Figure 3.

Representative images of how ERβ, unlike ERα, in astrocytes does not mediate reduction of CD3 T cells and Iba-1 globoid macrophages in EAE spinal cord. A, B, CD3 T cells and Iba-1 globoid macrophages are increased in WT and aCKO-ERα mice with EAE compared with WT mice without EAE. Treatment with ERα ligand prevents this increase in WT, but not aCKO-ERα, mice with EAE. C, D, CD3 T cells and Iba-1 globoid macrophages are increased in WT and aCKO-ERβ mice with EAE compared with WT mice without EAE. Treatment with ERβ ligand did not prevent this increase in either WT or aCKO-ERβ mice. Scale bars: A, C, 41 μm; D, 27 μm.