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. 2013 Jun 26;33(26):10924–10933. doi: 10.1523/JNEUROSCI.0886-13.2013

Figure 7.

Figure 7.

ERα is required on astrocytes to reduce CCL7 expression within reactive astrocytes. A, CCL7 (red), GFAP (green), and DAPI (blue) are expressed in EAE spinal cord in a WT mouse with EAE. Scale bar, 120 μm. B, CCL7 is coexpressed with GFAP. Scale bar, 27 μm. C, CCL7 is not coexpressed in infiltrating immune cells (DAPI). Scale bar, 27 μm. D, Treatment with ERα ligand was able to reduce coexpression of CCL7 with GFAP in WT, but not aCKO-ERα, mice with EAE. *p < 0.05 versus WT + No EAE and WT + EAE + ERα ligand (ANOVA with post hoc Bonferroni pairwise analysis). E, Treatment with ERβ ligand was not able to reduce coexpression of CCL7 with GFAP in WT or aCKO-ERβ mice with EAE. *p < 0.05 versus WT + No EAE (ANOVA with post hoc Bonferroni pairwise analysis). n = 5 per group.