Table 1.
Physiological data.
| Parameters | WT Saline | WT AII-1000 | WT AII-200 | −/− Saline | −/− AII-1000 | −/− AII-200 |
|---|---|---|---|---|---|---|
| Systolic Arterial | ||||||
| Pressure (mmHg) | ||||||
| Day 0 | 110 ± 4 | 115 ± 3 | 109 ± 4 | 116 ± 4 | 104 ± 3 | 107 ± 4 |
| Day 7 | 106 ± 3 | 135 ± 5* | 111 ± 3 | 110 ± 5 | 142 ± 8* | 109 ± 6 |
| Day 14 | 112 ± 3 | 134 ± 3* | 115 ± 4 | 109 ± 5 | 139 ± 4* | 109 ± 5 |
| Day 28 | 116 ± 4 | 128 ± 4* | 112 ± 4 | 113 ± 4 | 133 ± 5* | 112 ± 3 |
| Cerebral Arterioles | ||||||
| Pressure (mmHg) | ||||||
| Systolic | 49 ± 4 | 47 ± 3 | 57 ± 2 | 48 ± 4 | 46 ± 4 | 53 ± 2 |
| Diastolic | 34 ± 3 | 34 ± 2 | 41 ± 1 | 34 ± 3 | 35 ± 3 | 39 ± 2 |
| Mean | 39 ± 3 | 38 ± 3 | 46 ± 1 | 39 ± 3 | 39 ± 4 | 44 ± 2 |
| Pulse | 15 ± 1 | 13 ± 1 | 16 ± 1 | 14 ± 1 | 11 ± 1 | 14 ± 1 |
| Elastic Modulus | 6.7 ± 0.7 | 5.1 ± 0.4* | 6.9 ± 0.3 | 6.7 ± 0.8 | 5.9 ± 0.5 | 6.3 ± 0.6 |
| Arterial Blood Gases | ||||||
| pH | 7.35 ± 0.04 | 7.34 ± 0.02 | 7.38 ± 0.02 | 7.38 ± 0.03 | 7.39 ± 0.02 | 7.35 ± 0.02 |
| pCO2 | 30 ± 4 | 33 ± 2 | 28 ± 1 | 24 ± 2 | 29 ± 2 | 32 ± 2 |
| pO2 | 112 ± 7 | 99 ± 4 | 107 ± 5 | 113 ± 9 | 105 ± 8 | 94 ± 4 |
| Age (week) | 16.6 ± 0.9 | 17.8 ± 0.8 | 17.6 ± 1.0 | 17.4 ± 0.9 | 18.5 ± 0.8 | 17.9 ± 0.9 |
| Weight (g) | 26.1 ± 1.3 | 26.4 ± 2.0 | 26.8 ± 1.3 | 24.5 ± 1.0 | 23.8 ± 1.5 | 25.8 ± 0.9 |
| n | 10 | 10 | 10 | 10 | 10 | 10 |
Systolic arterial pressure, cerebral arteriolar pressure, internal diameters, elastic modulus, and arterial blood gases in wild-type (WT) and Nox2 deficient (−/−) mice treated with angiotensin II (AII, 200 or 1000 ng/kg/min). Systolic arterial pressure was measured using the tail-cuff method in conscious mice. Cerebral arteriolar pressure was measured under anesthetized condition. Values are mean ± SEM.
*
P < 0.05 vs. WT saline group.