Figure 1.

Neurogenic niches in the adult brain. (A) Schematic representation of the neurogenic regions in the adult rodent brain: the subgranular zone (SGZ) in dentate gyrus (DG) of the hippocampus, and the subventricular zone (SVZ) in the later wall of the lateral ventricles. (B) SVZ niche composed of type B1 cells, that corresponds to neural stem cells, type C cells that rapidly proliferate and type A neuroblasts, which migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB) where they mature into interneurons. (C) Neurogenesis in the SGZ. Radial type 1 cells give rise to type 2 cells that differentiate into type 3 neuroblasts that become immature neurons and then mature into granule neurons that migrate into the granule cell layer.